Our structural work on natural products (NP) with potent activity against the essential processes of protein homeostatis in the TB bacillum has reached a significant milestone. Structures of the complex of two active NP agents targeting the ClpC1 component, complexed with the N-terminal Domain (NTD) of ClpC1 (i.e. ClpC1-NTD) have been solved in our laboratory and reported to the community. The ClpC1-NTD-Rufomycin complex was published early this year, and the ClpC1-NTD-Ecumicin complex was presented by Nina Wolf (senior postdoc in the group) at the Annual ACA conference in Covington, KY this summer.
Further details in the attached abstract.